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Literature summary for 2.7.11.22 extracted from

  • Wang, Q.S.; Zhang, C.L.; Hou, L.Y.; Zhao, X.L.; Yang, X.W.; Xie, K.Q.
    Involvement of cyclin-dependent kinase 5 in 2,5-hexanedione-induced neuropathy (2008), Toxicology, 248, 1-7.
    View publication on PubMed
Search for more literature for 2.7.11.22

Activating Compound

Activating Compound Comment Organism Structure
2,5-hexanedione CDK5 contents and activities in sciatic nerve of rats treated with 200 or 400 mg/kg 2,5-hexanedione are significantly increased in both the cytosolic and membrane fractions, increase of CDK5 content in both the cytosolic and membrane fractions of spinal cord in 200 and 400 mg/kg 2,5-hexanedione-treated rats are observed Rattus norvegicus
p35
-
 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
2,5-hexanedione activities of CDK5 in cerebral cortex of 200 or 400 mg/kg 2,5-hexanedione-treated rats are significantly decreased in both the cytosolic and membrane fractions, CDK5 activities are significantly decreased in the cytosolic fraction of spinal cord cord in 200 and 400 mg/kg 2,5-hexanedione-treated rats Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-
membrane
-
 Rattus norvegicus 16020
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cerebral cortex
-
 Rattus norvegicus
-
sciatic nerve
-
 Rattus norvegicus
-
spinal cord
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + histone H1
-
 Rattus norvegicus ADP + phosphorylated histone H1
-
 ?

Synonyms

Synonyms Comment Organism
Cdk5
-
 Rattus norvegicus
cyclin-dependent kinase 5
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
cyclin
-
 Rattus norvegicus